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patient care academics & research español refer a patient about us giving newsroom directions jobs contact us publications disclaimer huntsman cancer institute / research / cancer genetics / cancer susceptibility (including unclassified variance) cancer susceptibility (including unclassified variants) genetic variant databases link directly to databases >>> when testing a gene, many different types of genetic changes are identified. some genetic changes clearly impair the function of the gene (that is, they are pathogenic) and may cause disease. other genetic changes are benign – causing no problems with the gene and creating no medical problems for the individual. however, some genetic changes are not easily classified as either pathogenic or benign. these genetic changes are called unclassified variants. unclassified variants present a dilemma for researchers, clinicians, and patients – all of whom are seeking clear, informative genetic test results. when an unclassified variant is identified in a patient’s genetic test results, it is unknown whether or not that variant has caused or could cause disease in the patient (or his/her family members). many researchers are working to gain more information about variants to definitively classify them as benign or pathogenic. however, this research takes time. until a variant can be classified, care for patients and their relatives is typically planned using what is definitely known – with tailored treatment and screening recommendations based on the patient’s personal and family history rather than the genetic variant. researchers at huntsman cancer institute at the university of utah (hci) have been involved with unclassified variant research for many years. their research has focused on classifying variants in genes associated with hereditary cancer risk, including brca1 and brca 2 and the mismatch repair genes. to increase access to genetic variant information, we have created this portal. by following the links below, you can access multiple internal and external databases full of information on variants in genes associated with hereditary cancer. you can also review powerpoint slides, videos, and articles on the topic of genetic variants. these databases are updated frequently, so we encourage you to check back regularly. if you have questions on genetic variant research, please contact sean.tavtigian@hci.utah.edu . if you or one of your patients has received a genetic test result containing an unclassified variant and you are looking for additional clinical guidance, please contact the family cancer assessment clinic at hci at 801-587-9555. one of the genetic counselors can assist you. huntsman cancer institute and university of utah managed sites resource genes resource description hci brca1/2 classified variant database brca1/2 hci-exlovd.hci.utah.edu curated published data on variants hci brca1/2 prior probabilities database brca1/2 http://priors.hci.utah.edu/priors/ data on all possible single nucleotide substitutions in brca1/2 hci mmr: prior probabilities and classified variants database mismatch repair (mlh1, msh2, pms2, msh6) hci-lovd.hci.utah.edu/home.php data on all possible single nucleotide substitutions in the mmr genes external managed sites resource genes resource description lovd-for paraganglioma genes (fh, sdhx) lovd-for paraganglioma genes (fh, sdhx) chromium.liacs.nl/lovd_sdh/home.php curated published data on variants iarc tp53 tp53 p53.iarc.fr/ curated published data on germline and tumor variants insight mismatch repair/apc/cdh1 www.insight-group.org/variants/database/ curated published data on germline variants breast cancer information core brca1/2 research.nhgri.nih.gov/bic/ database of submitted vus information from researchers and clinicians, classifications if available evidence-based network for the interpretation of germline alleles (enigma) multiple enigmaconsortium.org/ submit variants for research publications clinical resources at huntsman cancer institute family cancer assessment clinic (fcac) - providing clinical genetics evaluations and hereditary cancer risk assessment for patients research resources at huntsman cancer institute cancer genetics study (cgs) - enrolling patients with personal or family histories that suggest increased cancer risk to gain and refine knowledge about hereditary cancer contact information huntsman cancer institute 2000 circle of hope salt lake city, ut 84112 cancer hospital 801-585-0100 general 801-585-0303 quick links about us find a doctor careers circle of hope blog news & events directions & parking giving site information patient rights & responsibilities disclaimer privacy statement non-discrimination policy copyright and trademarks all clinical services and programs are part of university of utah health hospitals and clinics © 2018 huntsman cancer institute at the university of utah social media

Informations Whois

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%% [2600:3c03:0000:0000:f03c:91ff:feae:779d REQUEST] >> iarc.fr
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domain: iarc.fr
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hold: NO
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admin-c: MS5771-FRNIC
tech-c: GR1378-FRNIC
zone-c: NFC1-FRNIC
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created: 01/01/1995
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nserver: ccpnvx.in2p3.fr [134.158.69.104]
source: FRNIC

registrar: GIP RENATER
type: Isp Option 1
address: 23-25 Rue Daviel
address: PARIS
country: FR
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website: http://www.renater.fr
anonymous: NO
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nic-hdl: IAFR1-FRNIC
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nic-hdl: MS5771-FRNIC
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anonymous: NO
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  REFERRER http://www.nic.fr

  REGISTRAR AFNIC

SERVERS

  SERVER fr.whois-servers.net

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  PORT 43

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  REGISTERED yes

ADMIN

  HANDLE MS5771-FRNIC

  TYPE PERSON

  CONTACT Michel Smans

ADDRESS
International Agency for Research on Cancer
150, cours Albert Thomas
69372 Lyon Cedex 8

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  SPONSOR GIP RENATER

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TECH

  HANDLE GR1378-FRNIC

  TYPE ROLE

  CONTACT GIP RENATER

ADDRESS
GIP RENATER
Ensam
151, boulevard de l'Hopital
75013 Paris

  COUNTRY FR

  PHONE +33 1 53 94 20 30

  FAX +33 1 53 94 20 31

  EMAIL rensvp@renater.fr

TROUBLE
Information: http://www.Renater.fr/
abuse reports, ... mailto:CertSVP@Renater.fr
questions: mailto:RenSVP@Renater.Fr

  ADMIN-C DV321-FRNIC

TECH-C
FS65-FRNIC
BT261-FRNIC
MD5336-FRNIC
SJ94-FRNIC
ED168-FRNIC
CT1053-FRNIC
SEH1-FRNIC
FXA1-FRNIC

  SPONSOR GIP RENATER

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  ANONYMOUS NO

  OBSOLETED NO

  SOURCE FRNIC

OWNER

  HANDLE IAFR1-FRNIC

  TYPE ORGANIZATION

  CONTACT International Agency for Research on Cancer

ADDRESS
150, cours Albert Thomas
69372 Lyon Cedex 8

  COUNTRY FR

  SPONSOR GIP RENATER

  CHANGED 2008-10-09

  ANONYMOUS NO

  OBSOLETED NO

  SOURCE FRNIC

DOMAIN

  STATUS ACTIVE

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  SPONSOR GIP RENATER

  EXPIRY DATE 31/12/2017

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  CHANGED 2016-12-31

  SOURCE FRNIC

  HANDLE NSL50420-FRNIC

NSERVER

  NS1.IARC.FR 193.51.164.138

  DNSEXT.IARC.FR 193.51.164.142

  CCPNTC3.IN2P3.FR 134.158.69.191

  CCPNVX.IN2P3.FR 134.158.69.104

  NAME iarc.fr

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